ABSTRACT
The COVID-19 epidemic is an unprecedented and major social and economic challenge worldwide due to the various restrictions. Inflow of infective immigrants have not been given prominence in several mathematical and epidemiological models. To investigate the impact of imported infection on the number of deaths, cumulative infected and cumulative asymptomatic, we formulate a mathematical model with infective immigrants and considering vaccination. The basic reproduction number of the special case of the model without immigration of infective people is derived. We varied two key factors that affect the transmission of COVID-19, namely the immigration and vaccination rates. In addition, we considered two different SARS-CoV-2 transmissibilities in order to account for new more contagious variants such as Omicron. Numerical simulations using initial conditions approximating the situation in the US when the vaccination program was starting show that increasing the vaccination rate significantly improves the outcomes regarding the number of deaths, cumulative infected and cumulative asymptomatic. Other factors are the natural recovery rates of infected and asymptomatic individuals, the waning rate of the vaccine and the vaccination rate. When the immigration rate is increased significantly, the number of deaths, cumulative infected and cumulative asymptomatic increase. Consequently, accounting for the level of inflow of infective immigrants may help health policy/decision-makers to formulate policies for public health prevention programs, especially with respect to the implementation of the stringent preventive lock down measure.
ABSTRACT
This work aims at a better understanding and the optimal control of the spread of the new severe acute respiratory corona virus 2 (SARS-CoV-2). A multi-scale model giving insights on the virus population dynamics, the transmission process and the infection mechanism is proposed first. Indeed, there are human to human virus transmission, human to environment virus transmission, environment to human virus transmission and self-infection by susceptible individuals. The global stability of the disease-free equilibrium is shown when a given threshold T 0 is less or equal to 1 and the basic reproduction number R 0 is calculated. A convergence index T 1 is also defined in order to estimate the speed at which the disease extincts and an upper bound to the time of infectious extinction is given. The existence of the endemic equilibrium is conditional and its description is provided. Using Partial Rank Correlation Coefficient with a three levels fractional experimental design, the sensitivity of R 0 , T 0 and T 1 to control parameters is evaluated. Following this study, the most significant parameter is the probability of wearing mask followed by the probability of mobility and the disinfection rate. According to a functional cost taking into account economic impacts of SARS-CoV-2, optimal fighting strategies are determined and discussed. The study is applied to real and available data from Cameroon with a model fitting. After several simulations, social distancing and the disinfection frequency appear as the main elements of the optimal control strategy against SARS-CoV-2.